Videos and lectures are popular and accessible about the antioxidant SkQ1, Skulachev ions, the aging mechanism and ways to stop aging. Let's watch, listen and share links with everyone who is interested!
Biological aging (narrated by biologist Maxim Skulachev)
Aging is a biological process of gradual disruption and loss of important functions of the body or its parts, in particular the ability to reproduce and regenerate. As a result of aging, the body becomes less adapted to environmental conditions, reduces and loses its ability to fight predators and resist diseases and injuries... Biologist Maxim Skulachev says. Program "Units of Meaning"
Is it possible to defeat aging? How to live longer and feel healthy!
Boris Fenyuk, Associate Professor of the Faculty of Bioengineering and Bioinformatics of Moscow State University, Candidate of Biological Sciences, SkQ project employee visited the @NACHISTOTU channel. How does the body age and is it possible to slow down this process? How to live longer and feel healthy? Is it possible to avoid age-related diseases? Are there anti-aging eye drops and cosmetic creams? Does fasting help you live longer? Answers to these and many other questions await you in this video. Enjoy watching!
Video navigation: 1:10 Ways to stop aging 2:30 Existing anti-aging remedies 3:05 Restrictions as a way to live longer 4:00 Is the right lifestyle a guarantee of longevity? 5:00 Life expectancy statistics 6:20 Are there places where people live longer? 7:00 film “The Rules of Life of a 100-Year-Old Man” https://www.youtube.com/watch?v=m7vWP... 8:25 Have medications been invented to increase life expectancy? 10:30 Eye drops as a cure for aging 12:10 Difficulties in bringing a new drug to market 13:25 Restoring vision in dogs 15:50 Suppression of reactive oxygen species in cells 17:55 How does aging occur? 19:20 Life expectancy in men 19:56 Stem cells as a way to prolong life 22:50 Does fasting prolong life? 24:20 Clive Mackay's experiment 27:00 Is it possible to reverse aging? 28:00 Who lives the longest? 29:20 122 years, a longevity record? 30:40 Long-livers of the Caucasus 31:50 Average life expectancy in the world 33:10 Factors influencing life expectancy 34:10 At what age does human aging begin? 36:05 Immune system 37:55 Average age of Olympic champions 39:40 Sober thinking and age-related pathologies 40:50 Organisms that do not age 41:30 Naked mole rat 46:50 Will life expectancy increase in the future? We express our deep gratitude to the CHISTOTU channel for this video.
How to overcome old age? Maxim Skulachev, TEDx LavrushinskyLn
Maxim Skulachev, a hereditary biologist, talks about the many years of work of his father, Academician of the Russian Academy of Sciences Vladimir Petrovich Skulachev and the team he created, to create a cure for aging. Based on the invented drug SkQ1 and observations of its use, scientists have proven the possibility of defeating aging, which has become a purely technological task. Maxim Skulachev is a biologist, inventor of drugs that slow down aging. Since 2005, he has been one of the leaders of the biomedical project “Practical Application of Skulachev’s Ions,” created under the auspices of Moscow State University for the development of drugs based on a new type of active substances—mitochondrially targeted antioxidants. Author of more than 40 articles in international scientific journals, more than 50 patents and patent applications in the USA, Europe, Russia and other countries. Winner of the Scopus Award Russia for scientific and innovative activities in the field of biotechnology and medicine in 2014.
We and science. Science and us. Genetic engineers will create a new civilization. Broadcast 12/07/2018
A program about how science will change our lives in the near future. From the next issue we learn that in 10 years genetic engineers will create a new civilization. Guests: Skeptics: Maxim Skulachev - molecular biologist, leading researcher at the A. N. Belozersky Research Institute of Physical and Chemical Biology, Moscow State University; Vyacheslav Moiseev – expert in philosophy and methodology of science, Doctor of Philosophy, head of the department of philosophy, biomedical ethics and humanities at Moscow State Medical University named after A. I. Evdokimov; Optimists: Stanislav Bushev - philosopher, deputy dean of the Faculty of Philosophy of Moscow State University named after M.V. Lomonosov; Pavel Volchkov is a molecular biologist, head of the Laboratory of Genomic Engineering at MIPT. 45 minutes
A series of articles by Maxim Skulachev in Forbes magazine about the mechanisms of evolution, the genetic program of aging and ways to prolong youth.
“A cure for old age may appear in pharmacies in two to three years.” Maxim Skulachev, director of the Research Institute of Mitoengineering at Moscow State University, stated this in an interview with RT. According to him, work on the drug began in Russia several years ago. The innovative biotechnology is based on a method of blocking free radicals in mitochondria using a special substance. According to RT’s interlocutor, in the foreseeable future a person will be able to double the period of youth of the body.” Excellent article with a lot of interesting details about Skulachev’s project!
Cosmopolitan recommends! "Mitovitan" in the selection of the coolest facial serums - light in texture, incredibly effective in impact, with a high concentration of active substances that can work wonders! Mitovitan anti-aging serum, developed by a group of scientists from Moscow State University - on the same list with such famous brands as Clinique, Chanel, EsteeLauder, YvesSaintLaurent and Givenchy - read more in the article “Choosing a facial serum: 8 bestsellers and 8 new products”, Cosmopolitan, 03-2017 .
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Academician Vladimir Skulachev came up with a powerful antioxidant.
- Academician Vladimir Skulachev
Academician Vladimir Skulachev came up with a powerful antioxidant with which he wants to slow down aging.
Recently, the first medicine from Skulachev appeared in pharmacies - eye drops. Soon they will start testing pills for most age-related diseases. In July, “Visomitin” appeared in Moscow pharmacies - eye drops from academician Vladimir Skulachev , the world’s first registered drug that penetrates mitochondria. And although the indications for the use of drops modestly include the disease “dry eye,” little known to the general public, they were bought by everyone who had heard anything about the academician’s work on a cure for old age.
At the Moscow State University pharmacy, a line lined up insistently demanded drops: “We heard that they came out, do you have them under the counter?” In another pharmacy, someone bought a hundred bottles at once. “It’s good if it’s for small-scale commerce,” says Vladimir Skulachev. - God forbid he drinks. After all, there is an antibacterial agent that is not harmless in large doses, which is added to all eye drops. This is medicine, you need to follow the instructions, and not drink as you please!” Clinical trials conducted before the release of Vizomitin to the market showed that an incurable disease of the lacrimal gland - dry eye - responds well to therapy. More than 60% of subjects noted a significant improvement in their eye condition. For comparison, some of the subjects used moisturizing drops from a well-known Western company, and the results were three times worse. Clinical trials of drops against cataracts have already been completed, and trials against glaucoma are nearing completion; the results will be officially announced in the near future, but it is already known that the drops are very effective. An old woman, one of the subjects, who went only with guides, after a couple of months she already appeared at the doctor herself and, to the doctor’s surprised exclamations, answered: “Son, I can see it back!” Stories about dogs, horses, and now old women regaining their sight make skeptics grin. But they are not averse to trying the drops: there will be no harm, but what if they slow down aging! The academician himself, by dripping his own drops for four years, defeated a cataract in one eye and seriously reversed myopia. And in general he looks energetic.
About the clock, the program, mitochondria and plants
In his first interview with Expert in 2005, Academician Skulachev, talking about his hypothesis of programmed aging and the mechanism through which the program is implemented, cautiously warned: “It may turn out that I’m wrong.” But even then he was sure that the product he created would improve the condition of the body. Now Skulachev is much more confident in his hypothesis: science is adding more and more facts to his piggy bank. Well, many years of testing the substance he invented has already shown its effectiveness.
Scientists had to urgently look for a new investor: not only because expensive clinical trials of the drops had already started, but also because this was required by the agreement with Rusnano. They were lucky again. One of the Moscow State University graduates, the owner of an IT company, became interested in the project. He agreed to take over the investor baton. The project, agreed upon by Rusnano, involved investments in the amount of 1.4 billion rubles from the corporation and a co-investor. Prior to this, approximately $24 million had already been invested in it. For this money, many scientific groups, including foreign ones, worked, an experimental certified production facility was built, a modern vivarium was opened at Moscow State University, several series of clinical trials were conducted, and trials of the drug were launched in the USA and Great Britain. By Russian standards, the investments are significant, although a Big Pharma representative can spend more than a billion dollars on one medicine. But it also “beats them off” quickly enough. “We are already making money too,” laughs Vladimir Skulachev. — The first batch of drops was swept off the shelves in a few days. We are now certifying the next batch.” The cost of a bottle of drops is about 500 rubles, and the initial proceeds from the sale are half a million rubles in just five days. But this is just the beginning!
Mitotech plans to begin negotiations with big pharma if a number of clinical trials for the treatment of eye diseases are successful. In the meantime, the innovative company has a commercial product for dry eyes, clinical trials of drops against cataracts have ended (the data is being processed, but it is already clear that the product is highly effective), clinical trials of drops against glaucoma are ongoing, and in the fall trials of drops against age-related macular degeneration will begin ( retinal damage). If all these fairly common and poorly or generally incurable eye diseases respond to Skulachev’s drops, it will be a success that will undoubtedly be of interest to large pharmaceutical companies. By the way, Mitotech is preparing a worthy basis for such agreements not only in Russia: preclinical trials of drops are ending in the USA.
For heart attack, sore joints and baldness
Drops come drops, but everyone is waiting for a universal pill against old age from Skulachev. A couple of years ago he showed grayish-brown pills - the first prototypes of anti-aging pills. Since then they have been improved, and now the substance in them is more stable. In a few months, Mitotech plans to submit an application to the Ministry of Health for permission to clinical trials of the tablets. “While these will be safety tests, volunteers will take part in them,” says Maxim Skulachev. The company has not yet decided on further tactics. “There are two paths we can take,” says Vladimir Skulachev. — Clearly develop eye diseases and enter the world market with these indications or begin trials on one of those age-related diseases that covers millions. Most likely, it will be some kind of cardiovascular disease.” The company has a year to come to a definite decision.
Although the tablet, which will carry the substance throughout the body through the bloodstream, theoretically has systemic effects, trials will be conducted on specific indications. The enumeration of diseases characteristic of elderly and senile age will take more than one page. These are cardiovascular, autoimmune and associated with weakened immunity, as well as neurodegenerative, hormonal changes. Experiments on animals have already begun. In particular, in experiments on mice and rats, it was shown that SkQ1 reduces the area of myocardial infarction and stroke, relieves cardiac arrhythmia, and saves from death due to kidney infarction. In the mice tested, baldness, graying, and the development of osteoporosis were inhibited. Females did not stop estrous cycles, and males did not lose sexual motivation. SkQ1 also significantly inhibited age-related degeneration of the thymus (the organ responsible for the production of immune system cells). It is known that in humans the thymus begins to age in youth, weakening the immune system.
- Academician Skulachev’s laboratories are already working on the market Photo: Oleg Serdechnikov
Thus, it is capable of creating a whole line of unique innovative drugs that can become very attractive products for global pharmaceuticals. In parallel, scientists will conduct further research that would help convincingly show that aging is a program that can be reversed. One of the areas of scientific activity is the search for a substance that could be a measure of age (by analogy with radiocarbon 14C, the content of which is used to date various biological remains). “This must be a substance that changes with age not biologically, but chemically,” explains Vladimir Skulachev, “for example, some amino acid. It is known that in mammals all amino acids in proteins have the form of the L isomer. If you place an amino acid solution in a sealed ampoule, then after a short time there will be equal amounts of L and D isomers. But the problem is that this will happen after 250 years. However, just recently we came up with one crazy idea about what substance could be used to measure age, and we will test it.”
The company's scientific plans include testing the mechanism associated with cell death due to the action of free radicals. The research will be carried out in collaboration with Nobel laureate biochemist Aaron Ciechanover from Israel. The hypothesis is this: cells die due to apoptosis, which is caused by free radicals. The body, like the director of a factory, will first save not on workers, but on the servicing apparatus. According to Vladimir Skulachev, the body begins to economize on those molecules that control the quality of proteins, as a result of which damage begins to accumulate in the cells. “It struck me that this hypothesis reconciles two conflicting views on aging,” says Skulachev. - If this is true, then aging is a program that leads to the accumulation of errors! And when too many of these errors have accumulated, nothing can cure them, not even our SkQ. In a very old rat, SkQ does not cure blindness.” This study is also important from the point of view of when to start treating aging diseases in order to be young at a hundred years old.
