VIZIN CLASSIC

Visine

(eng.
Visine
) is a brand of eye drops, available in several versions with different compositions. Currently, the rights to the Visin trademark belong to Johnson & Johnson.

Contraindications

hypersensitivity to the components of the drug;

angle-closure glaucoma;

endothelial-epithelial dystrophy of the cornea;

children under 2 years of age.

Carefully

for the following diseases and conditions:

severe cardiovascular diseases (coronary artery disease, arterial hypertension, arrhythmia, aneurysm);

hyperthyroidism;

pheochromocytoma;

diabetes;

combination with MAO inhibitors or other drugs that can increase blood pressure.

Indications for use

The drug Vizin is intended for the treatment of various ophthalmological pathologies of various origins. Despite the rather low level of likelihood of developing side effects, it is recommended to start using the medication only after consulting with your doctor or other experienced ophthalmologist.

for adults

The main conditions for which the use of Visin drops is prescribed are:

• allergic conjunctivitis;
• Congestion (redness), swelling, and watery eyes caused by various irritants (eg, smoke, dust, cosmetics, contact lenses, contaminants in water, or bright light).

for children

The use of Vizin in children under 2 years of age is unacceptable due to the insufficient number of medical studies on the feasibility and safety of use. For children over 2 years of age, the use of the drug is indicated for the same pathologies as for adult patients. At the age of 2 to 6 years, caution should be exercised when prescribing medication.

for pregnant women and during lactation

Due to the risk of common adverse reactions, the use of Visine during lactation and pregnancy must be carried out under the supervision of a specialist.

Overdose

Symptoms:

When used in accordance with the instructions, the risk of overdose is minimal. But in case of accidental exposure to the gastrointestinal tract, the following symptoms of overdose are possible: pupil dilation, nausea, cyanosis, fever, convulsions, tachycardia, cardiac arrhythmia, cardiac arrest, increased blood pressure, pulmonary edema, impaired respiratory function, central nervous system function and coma. The risk of overdose symptoms associated with drug absorption is high in newborns and young children, especially if swallowed.

Treatment:

administration of activated carbon, gastric lavage, oxygen inhalation, administration of antipyretics and anticonvulsants. To lower blood pressure, use phentolamine 5 mg in saline solution (iv, slowly) or 100 mg (orally). Vasopressor drugs are contraindicated in patients with low blood pressure. There is no known antidote for tetrizoline hydrochloride.

If any symptoms of overdose appear, consult a doctor immediately!

Description and composition

Visin eye drops are a colorless, transparent 0.05% solution. The active ingredient is tetrizoline hydrochloride. Each ml of solution contains 0.5 mg of the active ingredient.

Excipients:

• purified water;
• benzalkonium chloride;
• sodium chloride;
• sodium tetraborate;
• boric acid;
• disodium salt of ethylenediaminetetraacetic acid.

special instructions

Contact lenses should be removed before instilling the medicine and installed after about 15 minutes.

It is advisable to use Vizin® Classic only for mild eye irritation. If the condition does not improve within 48 hours or if irritation and redness persist or increase, you should discontinue the drug and consult a doctor. If you experience intense pain in the eyes, headache, loss of vision, sudden appearance of floating spots in front of the eyes, redness of the eyes, pain when exposed to light, or double vision, you should immediately consult a doctor.

Do not use Vizin® Classic if irritation or redness is associated with serious diseases of the organ of vision: infection, foreign body or chemical injury to the cornea.

If the medicine has become unusable or has expired, it should not be poured into wastewater or thrown into the street. You need to put it in a bag and put it in the trash container. These measures will help protect the environment.

Impact on the ability to drive a car and operate machinery.

In rare cases, after using Vizin® Classic eye drops, pupil dilation occurs and blurred vision occurs, which may affect the ability to drive a car or operate machinery.

Visine

Release form, composition and packaging

Eye drops 0.05% transparent, colorless. 1 ml tetrizoline hydrochloride 500 mcg. Excipients: boric acid, sodium chloride, disodium edetate, benzalkonium chloride solution 17%, sodium borate, purified water.

Clinical and pharmacological group: A drug with a vasoconstrictor effect for local use in ophthalmology.

pharmachologic effect

Alpha adrenergic agonist. Tetrizoline stimulates α-adrenergic receptors of the sympathetic nervous system, but has virtually no effect on β-adrenergic receptors. It has a vasoconstrictor effect and reduces tissue swelling. The effect of the drug begins a few minutes after instillation and lasts 4-8 hours.

Pharmacokinetics

Tetrizoline is practically not absorbed when applied topically. Detailed pharmacokinetic studies have not been conducted with eye drops.

Indications

• swelling and hyperemia of the conjunctiva, arising from allergies or caused by exposure to chemical and physical factors (smoke, dust, chlorinated water, light, cosmetics, contact lenses).

The drug is prescribed to adults and children over 2 years of age.

For children under 6 years of age, the drug is prescribed under the supervision of a physician.

Dosage regimen

Instill 1-2 drops into the lower conjunctival sac of the affected eye 2-3 times a day. Continuous use of the drug for more than 4 days is not recommended. When instilling, you must turn the bottle over. Avoid contact of the tip of the dropper with any surfaces.

Before instilling the drug, it is necessary to remove contact lenses and install them approximately 15 minutes after instillation.

Side effect

From the organ of vision: burning sensation, redness of the eye, pain and tingling in the eye, blurred vision, irritation of the conjunctiva, dilation of the pupil. The patient should be warned that if any adverse reactions develop, they should immediately consult a doctor.

Contraindications

• endothelial-epithelial dystrophy of the cornea;
• angle-closure glaucoma;
• children under 2 years of age;
• hypersensitivity to the components of the drug.

The drug should be used with caution in severe cardiovascular diseases (for example, coronary artery disease, arterial hypertension, arrhythmias, aneurysm), hyperthyroidism, diabetes mellitus, pheochromocytoma, and in patients receiving MAO inhibitors or other drugs that can increase blood pressure.

Pregnancy and lactation

Taking into account the risk of developing systemic adverse reactions, the use of the drug during pregnancy and lactation (breastfeeding) is possible only in cases where the expected benefit of therapy for the mother outweighs the potential risk for the fetus or infant.

special instructions

It is advisable to use Visine only for mild eye irritation. If the condition does not improve within 48 hours or irritation and hyperemia persist or increase, the doctor must verify the diagnosis.

The patient should be informed that if intense pain in the eyes, headache, loss of vision, sudden appearance of “floating” spots in front of the eyes, redness of the eyes when exposed to light, or double vision occurs, it is necessary to immediately consult a doctor. The drug should not be used if irritation or hyperemia is associated with serious diseases of the organ of vision, such as infection, foreign body or chemical trauma to the cornea.

Impact on the ability to drive vehicles and operate machinery

In rare cases, after using Visin eye drops, dilation of the pupil and blurred vision may occur, which may affect the ability to drive a car or operate machinery.

Overdose

When using the drug in accordance with the recommendations, the risk of overdose is minimal.

However, if the drug enters the gastrointestinal tract, the following symptoms are possible: pupil dilation, nausea, cyanosis, fever, convulsions, tachycardia, arrhythmia, cardiac arrest, arterial hypertension, pulmonary edema, respiratory dysfunction, central nervous system function, coma. The risk of overdose symptoms associated with drug absorption is especially high in newborns and young children (especially when swallowing drops).

Treatment: Monitoring of the patient's condition is recommended.

If necessary, activated charcoal, gastric lavage, oxygen inhalation, antipyretics and anticonvulsants are prescribed.

To lower blood pressure, it is possible to slowly administer 5 mg of phentolamine in saline intravenously or take phentolamine orally at a dose of 100 mg. Vasopressor drugs are contraindicated in patients with low blood pressure. A specific antidote is unknown.

Drug interactions

Drug interactions with Vizin have not been studied.

Storage conditions and periods

The drug should be stored out of the reach of children at a temperature not exceeding 30°C. Shelf life: 3 years.

Notes

1. [books.google.ru/books?ei=wDDrU8TQKab5yQPczYCABQ&hl=ru&id=MWUPAQAAMAAJ&dq=1958+visine+usa&focus=searchwithinvolume&q=visine Encyclopedia of Major Marketing Campaigns - Thomas Riggs]
2. [books.google.ru/books?ei=dpDoU4jqLaTMyAPI3IKgCw&hl=ru&id=rwkpAQAAMAAJ&dq=Advertising+Age%27s+100+leaders%27+marketing+profiles%2C+1971&focus=searchwithinvolume&q=visine Advertising Age's 100 leaders' marketing profiles, 1971]
3. [books.google.ru/books?id=WXLFlXyRxq4C&pg=PA231&dq=visine&hl=ru&sa=X&ei=-YToU_WBAuj44QScooCYDw&ved=0CCwQ6AEwAg#v=onepage&q=visine&f=false Value Above Cost: Driving Superior Financial Performance with CVA, the Most Important Metric You' ve Never Used — Donald E. Sexton]
4. [books.google.ru/books?id=HTcWAAAAQBAJ&printsec=frontcover&dq=Advertising+Promotion+and+Other+Aspects+of+Integrated+Marketing+Communications&hl=ru&sa=X&ei=v47oU_jLF6q_ygPvu4DwDA&ved=0CBoQ6AEwAA#v=onepage&q=visine&f=false Advertising Promotion and Other Aspects of Integrated Marketing Communications - Terence Shimp, J. Craig Andrews]
5. [www.vedomosti.ru/newspaper/article/2006/06/27/108615 $16 billion for the Pfizer part]. Gazette. Retrieved July 10, 2014.
6. [www.sostav.ru/news/2010/06/03/cod2/ JWT Russia created local creative for Vizin for the first time]
7. [www.visine.com/ Official website of the drug in English]
8. [www.dailymail.co.uk/news/article-2038986/Luciana-Reichel-jailed-90-days-Wedding-Crashers-eyedrop-stunt.html Student jailed for 90 days for putting eyedrops into her room-mate's water after seeing stunt on Wedding Crashers], Daily Mail
   (19 September 2011).
9. [www.snopes.com/medical/myths/visine.asp Visine Prank: Mickey Red Eyes]. Snopes
   (29 June 2009). Retrieved July 24, 2014.

An excerpt characterizing Vizin

Nothing is a reason. All this is just a coincidence of the conditions under which every vital, organic, spontaneous event takes place. And that botanist who finds that the apple falls because the fiber is decomposing and the like will be just as right and wrong as that child standing below who will say that the apple fell because he wanted to eat him and that he prayed about it. Just as right and wrong will be the one who says that Napoleon went to Moscow because he wanted it, and died because Alexander wanted his death: just as right and wrong will be the one who says that the one that fell into a million pounds the dug mountain fell because the last worker struck under it for the last time with a pickaxe. In historical events, the so-called great people are labels that give names to the event, which, like labels, have the least connection with the event itself. Each of their actions, which seems to them arbitrary for themselves, is in the historical sense involuntary, but is in connection with the entire course of history and is determined from eternity. On May 29, Napoleon left Dresden, where he stayed for three weeks, surrounded by a court composed of princes, dukes, kings and even one emperor. Before leaving, Napoleon treated the princes, kings and emperor who deserved it, scolded the kings and princes with whom he was not entirely pleased, presented the Empress of Austria with his own, that is, pearls and diamonds taken from other kings, and, tenderly hugging Empress Maria Louise, as his historian says, he left her saddened by the separation, which she - this Marie Louise, who was considered his wife, despite the fact that another wife remained in Paris - seemed unable to bear. Despite the fact that diplomats still firmly believed in the possibility of peace and worked diligently for this purpose, despite the fact that Emperor Napoleon himself wrote a letter to Emperor Alexander, calling him Monsieur mon frere [Sovereign my brother] and sincerely assuring that he did not want war and that he would always be loved and respected - he went to the army and gave new orders at each station, with the goal of hastening the movement of the army from west to east. He rode in a road carriage drawn by six, surrounded by pages, adjutants and an escort, along the highway to Posen, Thorn, Danzig and Konigsberg. In each of these cities, thousands of people greeted him with awe and delight. The army moved from west to east, and the variable gears carried him there. On June 10, he caught up with the army and spent the night in the Vilkovysy forest, in an apartment prepared for him, on the estate of a Polish count. The next day, Napoleon, having overtaken the army, drove up to the Neman in a carriage and, in order to inspect the area of ​​the crossing, changed into a Polish uniform and went ashore. Seeing on the other side the Cossacks (les Cosaques) and the spreading steppes (les Steppes), in the middle of which was Moscou la ville sainte, [Moscow, the holy city,] the capital of that similar Scythian state, where Alexander the Great went, - Napoleon, unexpectedly for everyone and contrary to both strategic and diplomatic considerations, he ordered an offensive, and the next day his troops began to cross the Neman. On the 12th, early in the morning, he left the tent, pitched that day on the steep left bank of the Neman, and looked through the telescope at the streams of his troops emerging from the Vilkovyssky forest, spilling over three bridges built on the Neman. The troops knew about the presence of the emperor, looked for him with their eyes, and when they found a figure in a frock coat and hat separated from his retinue on the mountain in front of the tent, they threw their caps up and shouted: “Vive l'Empereur! [Long live the Emperor!] - and one after another, without exhaustion, flowed out, they all flowed out of the huge forest that had hidden them until now and, upset, crossed three bridges to the other side. – On fera du chemin cette fois ci. Oh! quand il s'en mele lui meme ca chauffe... Nom de Dieu... Le voila!.. Vive l'Empereur! Les voila donc les Steppes de l'Asie! Vilain pays tout de meme. Au revoir, Beauche; je te reserve le plus beau palais de Moscow. Au revoir! Bonne chance... L'as tu vu, l'Empereur? Vive l'Empereur!.. preur! Si on me fait gouverneur aux Indes, Gerard, je te fais ministre du Cachemire, c'est arrete. Vive l'Empereur! Vive! vive! vive! Les gredins de Cosaques, comme ils filent. Vive l'Empereur! Le voila! Le vois tu? Je l'ai vu deux fois comme jete vois. Le petit caporal... Je l'ai vu donner la croix a l'un des vieux... Vive l'Empereur!.. [Now let's go! ABOUT! As soon as he gets involved, things will boil over. By God... Here he is... Hurray, Emperor! So here they are, the Asian steppes... However, it is a bad country. Goodbye, Bose. I will leave you the best palace in Moscow. Goodbye, I wish you success. Have you seen the emperor? Hooray! If they make me a governor in India, I will make you the minister of Kashmir... Hurray! The Emperor is here! Do you see him? I saw him twice since you. Little corporal... I saw how he hung a cross on one of the old men... Hurray, emperor!] - said the voices of old and young people, of the most diverse characters and positions in society. On all the faces of these people there was one common expression of joy at the beginning of the long-awaited campaign and delight and devotion to the man in a gray frock coat standing on the mountain.