Study of the effect of Oftan Katachroma on the development of macular degeneration of the retina (experimental study) | Gusarevich O.G., Fursova A.Zh., Kolosova N.G.

Catachrome eye drops (Oftan Katachrome) are an effective drug prescribed for the treatment of lens opacity - cataracts, especially in the initial stages of the pathological process.

Katachrom eye drops are a remedy that stimulates regenerative processes in all tissues of the eyeball - under its influence, metabolic processes in the tissues of the lens are activated and its cells are protected from the damaging effects of free radicals.

In addition, the drug has a moisturizing effect on the cornea of the eye, has an antimicrobial effect and suppresses unwanted inflammatory reactions, including those arising from everyday irritants.

Composition and release form

Oftan Katahrom eye drops are produced in the form of a transparent sterile solution, which is packaged in 10 ml dropper bottles. Instructions for using Katachrom eye drops are included in the package.

The composition of the complex medicinal product includes:

cytochrome C
nicotinamide
adenosine

as the main active ingredients, as well as a small amount of preservatives and ballast substances:

sorbitol
benzalkonium chloride
sodium phosphate
sodium succinate
water for injections

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Description of the product

Oftan Katochrome is a combination drug that improves the metabolism of the eye lens. The drops are transparent and have a red tint.

The solution is odorless, non-viscous, and very liquid.

Includes:

Main active ingredients: Cytochrome C in the amount of 0.675 mg, adenosine in the amount of 2 mg and nicotinamide in the amount of 20 mg. Volumes are indicated in the content of 1 ml of the drug.
Auxiliary components: sorbitol, purified water, benzalkonium chloride, sodium succinate hexahydrate, sodium dihydrogen phosphate dihydrate and others.

Each component from the active list plays a huge role. For example, Cytochrome C is the most important link in the biochemical redox processes of eyeball tissue and is an excellent antioxidant. Adenosine is involved in the metabolic processes of the lens, and nicotinamide stimulates the synthesis of nicotinamide nucleotide.

The drug is available without a prescription. But do not forget that before use you must consult an ophthalmologist. This article will tell you about laser correction of myopia.

While using the drops, you should discard soft contact lenses, and also remove the lenses from your eyes before use, and return them back approximately 25 minutes after instilling the drops.

pharmachologic effect

The effects of using Katachrom eye drops are explained by the action of the main components of the drug, under the influence of which the metabolism in the tissues of the optical lens of the eye (lens) is stimulated, its trophism is improved, and a complex effect against free radicals is exerted.

Cytochrome C suppresses the activity of free radicals by binding their molecules, so the drug has a protective (protective) effect on the lens and cornea of the eyeball - which is why the drug prevents the development and progression of cataracts.

Adenosine has a vasodilating effect and improves blood circulation in the blood vessels of the eye, activates the production and exchange processes of intraocular fluid, has an antioxidant effect, suppresses the inflammatory process and its severity in the tissues of the eyeball.

Nicotinamide activates restoration processes in lens cells, which is an effective means of preventing cataracts.

Indications and contraindications

Indications: drops are designed to combat cataracts of various origins and stages. As prescribed by a doctor, it can be used in the treatment of myopia. Read about the prevention of myopia in children at this link.

Can be used for myopia strictly as prescribed by a doctor.

Contraindications:

children under 18 years of age;
During pregnancy and breastfeeding;
hypersensitivity to the components of the composition.

Side effects and overdose

During treatment, undesirable effects may occur both from the organs of vision and from the whole organism as a whole. Local side effects are limited to the appearance of irritation and redness of the eyes, which in the vast majority of cases go away on their own.

Systemic effects are explained by the presence of nicotinic acid derivatives in the Oftan Katahrom eye drops - nausea, redness of the face or any other part of the body, attacks of shortness of breath, palpitations and instability of blood pressure may appear.

In addition, the development of allergic reactions is possible - contact dermatitis is most often found on the eyelids. If you follow your doctor's recommendations, the drug does not interact with other medications.

Oftan katachrome

Oftan Katahrom (cytochrome C + adenosine + nicotinamide) is a stimulator of tissue repair. Used to treat cataracts of various origins. Cytochrome C is an active participant in redox reactions in eye tissues and a pronounced antioxidant. Adenosine is involved in metabolic processes occurring in the lens - a transparent body located inside the eyeball opposite the pupil, which is a key element of the optical system of the eye. Nicotinamide activates the formation of the cofactor dehydrogenase nicotinamide dinucleotide, which, in turn, has a positive effect on the metabolism of eye tissue. When instilled into the eye, cytochrome C does not penetrate the systemic bloodstream and undergoes a full cycle of metabolic transformations, being broken down in the same way as amino acids. Adenosine easily penetrates the cornea of the eye. The half-life of this substance in the blood does not exceed one minute. Adenosine is metabolized to form inosine, xanthine and urate, which are freely eliminated by the kidneys. Metabolites of ribose, a monosaccharide that is a component of adenosine, are burned in the processes of tissue respiration. Nicotinamide partially breaks down to nicotinic acid. Both of these compounds undergo further metabolism. Metabolites and the remainder of nicotinamide are excreted by the kidneys. Oftan Katahrom is contraindicated in case of individual intolerance to the active or auxiliary ingredients of the drug.

The drug is not used in pediatric practice. The use of Oftan Katahrom by pregnant women and nursing mothers is possible only after consultation with a doctor, who must compare the expected effect of pharmacotherapy with its potential risk for the mother, fetus and child. Single dose - 1-2 drops in one eye. Frequency of use: 3 times a day. When using the drug, only local side effects are possible: transient burning of the eyes, allergic inflammation of the outer membrane of the eye, skin reactions. Systemic side effects (nausea, decreased blood pressure, vertigo, shortness of breath) develop very rarely. It is necessary to warn the patient that nicotinic acid, a metabolite of nicotinamide, has a vasodilating effect and can provoke a feeling of heat and throbbing in the temples. Taking Oftan Katahrom is incompatible with wearing soft contact lenses, because The preservative present in the drug as an excipient can accumulate in the lens and subsequently negatively affect the eye tissue. If a patient experiences short-term adverse reactions to taking the drug (irritation, itching), then he should refrain from engaging in potentially dangerous activities that require visual acuity. After using the drug, contact lenses are put on 15 minutes after instillation.

Analogs

Oftan Katahrom, although an effective drug, people sometimes choose cheaper drugs, drugs approved for children, or drugs with other components in their composition. The cost of a package varies between 280-330 rubles, the package lasts for a month, so people with a long course will have to spend money. There are a large number of analogues of Oftan Katahrom, namely:

Taurine . This drug can be used to treat myopia, degenerative processes of the cornea and retinal diseases. If prescribed by a doctor, it can be used as eye drops for glaucoma. The drug is approved for patients of any age, starting from 16 years. The course of treatment can begin at the age of 16, but only if there are no other drugs that could help in this situation. The cost per package is very low, no more than 20 rubles. The course of treatment is long, like Oftan Katahroma;
Vitafacol . This drug has almost the same composition as Oftan Katahrom. It is approved for use by people of any age and has no special contraindications, even allowed during pregnancy. If the drug is taken simultaneously with other eye drops, then after use you should wait about 20 minutes and use another product so as not to cause severe burning and tearing. The cost per package is no more than 300 rubles;
Ujala . This drug came to us from abroad. In most cases, it is not a medicine, but an eye tonic. Used for cataracts, glaucoma and various other eye diseases. The drug does not contain any chemical compounds or synthetic components, therefore, this drug is approved for all patients, even those for whom there were contraindications to other medications. The course is divided into two parts: the first part consists of 60 days, during which the patient’s vision improves significantly, followed by 12 months, when vision should be completely restored. Allowed for children over 12 years old. The cost per package is no more than 200 rubles;
Bestoxol . These drops help stimulate regenerative and repair processes that help improve the metabolism of human eye cells. The drug can cure various cataracts. The course of treatment is 3 calendar months, so it is very convenient for use. The drug is prohibited for persons under 18 years of age, but is allowed during pregnancy, and is also allowed when taking vitamins, since it does not penetrate the body and will not harm the child at all.

You can take the drug only after the recommendation of a doctor; in no case should you use drops without recommendations.

Eye drops SANTEN OFTAN katachrome – review

Three years ago in the winter I felt that my vision began to become very poor. I went to the best, by universal recognition. an ophthalmologist in our city (Bobruisk), but this doctor holds optics and immediately suggested glasses.

But unexpectedly I was lucky, she was urgently called somewhere and she left me with a girl intern, who advised me to take Oftan-Katachrome drops once a year, three times a day, and almost constantly drink Optix-Forte vitamins.

I categorically did not want to wear glasses, I was glad for the alternative and ran for the drops, without even studying the instructions. Drops are available without a prescription. The instructions confused me at first:

Indications for use

Cataracts of various origins

I didn't have any cataracts. But I decided to buy it and try it anyway.

Pharmachologic effect:

A combined drug that improves the energy metabolism of the lens.

Cytochrome C plays an important role in the biochemical process of reducing oxidation in the tissues of the eyeball. Sodium succinate is an activator of cell metabolism and respiration.

Adenosine, a precursor to ATP, takes part in the metabolic reactions of the lens. Nicotinamide stimulates the synthesis of NAD, a cofactor for dehydrogenases.

I have had laser correction done in the past. After the correction, my eyes feel dry in the morning, I start every day with a “natural tear”. In the autumn-winter period, when it gets dark early, I always begin to see worse.

Sometimes black rods and dots start flying in my eyes. My blood pressure is usually low, never high. Work - at the computer all day.

I was 37 years old when I first started using Oftan-Katachrome.

I drop “Oftan-katachrome” only once a day in the morning instead of my usual “tear”, when I feel that my vision is starting to worsen. Enough for a month. I don’t take vitamins at the same time, that is, the results come from the drops.

Side effects include short-term burning and tingling of the eyes. I only learned from the reviews here that other people experience other side effects.

Side effect

Local: short-term burning and tingling of the eyes. Contact allergy on the conjunctiva, contact dermatitis.

Systemic effects are extremely rare. Nausea, arterial hypotension, dizziness and shortness of breath for a very short time.

Nicotinic acid has a vasodilating effect and can cause hot flashes, a feeling of heat, fainting and a sensation of pulsation in the temples.

But the result impressed me, and instantly. No sooner had I applied the drops than the sharpness of my vision immediately increased. And it stays like that for the whole day. And nothing flashes in your eyes anymore. “Oftan-katachrome” saved me from returning to the hated glasses.

I also recommended these drops to my colleagues. She just warned me to look into the contraindications first. One is 50 years old, suffered a mini-stroke, menopause, came to ask about laser correction, and ended up purchasing “Oftan-Katachrome”.

We had a conversation on Friday, on Monday I came to thank him and said that I felt like I had wiped dirty glass. I'm not thinking about laser correction yet. Two more colleagues over 60 years of age were interested in whether I was dripping - I was afraid of the bottom without a doctor’s prescription, but the second decided. She also thanked me for the tip.